WHAT’S THE ROLE OF THE ARYL HYDROCARBON RECEPTOR
(AHR) IN PLAQUE PSORIASIS?2
AhR is a ligand-dependent transcription factor that regulates diverse, multifunctional pathways. It plays an important balancing role in skin homeostasis.
AhR signaling could help restore order and balance to the dysregulated mechanisms in plaque psoriasis because:
AhR suppresses Th17 cell growth and production of key cytokines, such as IL-17 and IL-2212
AhR upregulates the production of skin barrier proteins to restore skin barrier function2
AhR induces the Nrf2 transcription factor pathway to increase antioxidant activity17
You’ll have seen mechanism of disease videos before, but we’re sure you’ve never seen one like this! Skin City dramatizes the plight of the cells and systems involved in plaque psoriasis to explain the mechanism of disease in an unforgettable style.
Albert Henry Roberts (better known as AhR) used to help maintain order in Skin City. But since plaque psoriasis came to town, he’s lost control. Now the cytokines have overrun the city he loves; flare smoke billows overhead, and there’s trouble around every corner.
Watch the videos below to see how psoriasis turned Skin City from a nice place to a plaque
THE SCIENCE BEHIND TAPINAROF
The specific mechanisms by which VTAMA® (tapinarof) cream, 1% exerts its therapeutic action in patients with psoriasis are unknown. The Aryl hydrocarbon Receptor (AhR) is a ligand-dependent transcription factor that helps regulate diverse pathways, like decreasing inflammation, reducing oxidative stress, and normalizing skin barrier functions. Tapinarof, in VTAMA cream, supports these natural pathways.2,12